Duchenne's muscular dystrophy (DMD), which affects 1/3500 live male births, involves a progressive degeneration of skeletal and cardiac muscle, leading to early death. The protein dystrophin is lacking in DMD and present, but defective, in the allelic, less severe, Becker muscular dystrophy and is also missing in the mdx mouse. Experiments on the mdx mouse have suggested two possible therapies for these myopathies. Implantation of normal muscle precursor cells (mpc) into mdx skeletal muscle leads to the conversion of dystrophin‐negative fibres (...) to ‐positive, with consequent improvement in muscle histology. Direct injectidn of dystrophin cDNA into skeletal or cardiac muscle also gives rise to dystrophin‐positive fibres. Although both appear promising, there are a number of questions to be answered and refinements to be made before either technique could be considered possible as treatments for myopathies in man. (shrink)

Ancient DNA has been discovered in many types of preserved biological material, including bones, mummies, museum skins, insects in amber and plant fossils, and has become an important research tool in disciplines as diverse as archaeology, conservation biology and forensic science. In archaeology, ancient DNA can contribute both to the interpretation of individual sites and to the development of hypotheses about past populations. Site interpretation is aided by DNA‐based sex typing of fragmentary human bones, and by the use of genetic (...) techniques to assess the degree of kinship between the remains of different individuals. On a broader scale, population migrations can be traced by studying genetic markers in ancient DNA, as in recent studies of the colonisation of the Pacific islands, while ancient DNA in preserved plant remains can provide information on the development of agriculture. (shrink)

Catholic theology’s traditional understanding of the spiritual nature of the human person begins with the idea of a rational soul and human mind that is made manifest in free will—the spiritual experience of the act of consciousness and cause of all human arts. The rationale for this religion-based idea of personhood is key to understanding ethical dilemmas posed by modern research that applies a more empirical methodology in its interpretations about the cause of human consciousness. Applications of these beliefs about (...) the body/soul composite to the theory of evolution and to discoveries in neuroscience, paleoanthropology, as well as to recent animal intelligence studies, can be interpreted from this religious and philosophical perspective, which argues for the human soul as the unifying cause of the person’s unique abilities. Free will and consciousness are at the nexus of the mutual influence of body and soul upon one another in the traditional Catholic view, that argues for a spiritual dimension to personality that is on a par with the physical metabolic processes at play. Therapies that affect consciousness are ethically problematic, because of their implications for free will and human dignity. Studies of resilience, as an example, argue for the greater, albeit limited, role of the soul’s conscious choices in healing as opposed to metabolic or physical changes to the brain alone. (shrink)

This book explores the principal issues involved in bridging the gap between the pure theory of consumer behavior and its empirical implementation. The authors focus upon the structure of preferences, the treatment of demographic variables, the treatment of dynamics, and the specification of the stochastic structure of the demand system.

Based on theoretical considerations of Aurell (1979) and Block (1995), we argue that object recognition awareness is distinct from purely sensory awareness and that the former is mediated by neuronal activities in areas that are separate and distinct from cortical sensory areas. We propose that two of the principal functions of neuronal activities in sensory cortex, which are to provide sensory awareness and to effect the computations that are necessary for object recognition, are dissociated. We provide examples of how this (...) dissociation might be achieved and argue that the components of the neuronal activities which carry the computations do not directly enter the awareness of the subject. The results of these computations are sparse representations (i.e., vector or distributed codes) which are activated by the presentation of particular sensory objects and are essentially engrams for the recognition of objects. These final representations occur in the highest order areas of sensory cortex; in the visual analyzer, the areas include the anterior part of the inferior temporal cortex and the perirhinal cortex. We propose, based on lesion and connectional data, that the two areas in which activities provide recognition awareness are the temporopolar cortex and the medial orbitofrontal cortex. Activities in the temporopolar cortex provide the recognition awareness of objects learned in the remote past (consolidated object recognition), and those in the medial orbitofrontal cortex provide the recognition awareness of objects learned in the recent past. The activation of the sparse representation for a particular sensory object in turn activates neurons in one or both of these regions of cortex, and it is the activities of these neurons that provide the awareness of recognition of the object in question. The neural circuitry involved in the activation of these representations is discussed. (shrink)

Since the early 1980’s, with the clinical advent of in vitro fertilization resulting in so-called “test tube babies,” a wide array of ethical considerations and concerns regarding artificial womb technology (AWT) have been described. Recent breakthroughs in the development of extracorporeal neonatal life support by means of AWT have reinitiated ethical interest about this topic with a sense of urgency. Most of the recent ethical literature on the topic, however, pertains not to the more imminent scenario of a physiologically improved (...) method of neonatal care through AWT, but instead to the remote scenario of “complete ectogenesis” that imagines human gestation occurring entirely outside of the womb. This scoping review of the ethical literature on AWT spans from more abstract concerns about complete ectogenesis to more immediate concerns about the soon-to-be-expected clinical life support of what we term the fetal neonate or fetonate. Within an organizing framework of different stages of human gestational development, from conception to the viable premature infant, we discuss both already identified and newly emerging ethical considerations and concerns regarding AWT and the care of the fetonate. (shrink)

It has been shown that visual awareness in the blind hemifield of hemianopic cats that have undergone unilateral ablations of visual cortex can be restored by sectioning the commissure of the superior colliculus or by destroying a portion of the substantia nigra contralateral to the cortical lesion (the Sprague effect). We propose that the visual awareness that is recovered is due to synchronized oscillatory activities in the superior colliculus ipsilateral to the cortical lesion. These oscillatory activities are normally partially suppressed (...) by the inhibitory, GABAergic contralateral nigrotectal projection, and the destruction of the substantia nigra, or the sectioning of the collicular commissure, disinhibits the collicular neurons, causing an increase in the extent of oscillatory activity and/or synchronization between activities at different sites. This increase in the oscillatory and synchronized character is sufficient for the activities to give rise to visual awareness. We argue that in rodents and lower vertebrates, normal visual awareness is partly due to synchronized oscillatory activities in the optic tectum and partly due to similar activities in visual cortex. It is only in carnivores and primates that visual awareness is wholly due to cortical activities. Based on von Baerian recapitulation theory, we propose that, even in humans, there is a period in early infancy when visual awareness is partially due to activities in the superior colliculus, but that this awareness gradually disappears as the nigrotectal projection matures. (shrink)

Recent experiments have shown that the amplitudes of cortical gamma band oscillatory activities that occur during anesthesia are often greater than amplitudes of similar activities that occur without anesthesia. This result is apparently at odds with the hypothesis that synchronized oscillatory activities constitute the neural correlate of consciousness. We argue that while synchronization and oscillatory patterning are necessary conditions for consciousness, they are not sufficient. Based on the results of a binocular rivalry study of Fries et al. (1997), we propose (...) that the degrees of oscillatory strength and synchronization of neuronal activities determine the degree of awareness those activities produce. On the other hand, the overal firing rates of neurons in cortical sensory areas are not correlated with the degree of awareness the activities of those neurons produce. The results of the experiment of Fries et al. (1997) appear to conflict with the results of another binocular rivalry experiment, in which monkeys were trained to pull a lever in order to report which stimulus object was being perceived (Leopold & Logothetis, 1996). In the latter experiment, it was demonstrated that the firing rates of neurons in striate cortex did not change during perceptual alterations, while 90% of neurons in inferior and superior temporal cortices changed their firing rate when the perceived image changed. This result led to the conclusion that activities in temporal cortex are correlated with visual awareness, but those in striate cortex are not. We argue that activities in temporal cortex contribute little, if anything, to perceptual awareness, and that their primary function is computational. Thus the correlation between the firing rates of neurons in these areas and the responses of the monkeys is due to the recognition of a particular stimulus object, which in turn is due to the computations made there. (shrink)

The neural and endocrine bases of the generation of thirst are reviewed. Based on this review, a hierarchical system of neural structures that regulate water conservation and acquisition is proposed. The system includes primary sensory-receptive areas; secondary sensory structures (circumventricular organs), which detect levels of hormones, including angiotensin II and vasopressin, which are involved in generating thirst; preoptic and hypothalamic structures; and an area within the ventrolateral quadrant of the periaqueductal gray matter. Hodological and other data are used to determine (...) the hierarchical organization of the system. Based on studies of the effects of lesions to various structures within the hierarchy of the system, it is proposed that the awareness of thirst in rodents is either entirely or predominantly due to neuronal activities in a subsection of the ventrolateral periaqueductal gray matter. It is also hypothesized that the awareness of thirst in primates is due to neuronal activities in both the ventrolateral periaqueductal gray and in a region within the medial prefrontal and anterior cingulate cortex. (shrink)

Building on the strengths of the first edition, the second edition of the Irwin Nicomachean Ethics features a revised translation (with little editorial intervention), expanded notes (including a summary of the argument of each chapter), an expanded Introduction, and a revised glossary.

What can we learn about management ethics from other cultures and societies? In this textbook, cross-cultural management theory is applied and made relevant to management ethics. To help the reader understand different approaches that global businesses can take to operate successfully and ethically, there are chapters focusing on specific countries and regions. As well as giving the wider geographical, political and cultural contexts, the book includes numerous examples in every chapter to help the reader critique universal assumptions of what is (...) ethical. By taking a closer look at the way we view other cultures and their values, the author challenges us to rethink commonly held assumptions and approaches in cross-cultural management, and to apply a more critical approach. (shrink)

Genome‐wide identification of transcription factor binding sites with the ChIP‐seq method is an extremely important scientific endeavor − one that should ideally be performed for every transcription factor in as many cell types as possible. A major hurdle on the way to this goal is the necessity for a specific, ChIP‐grade antibody for each transcription factor of interest, which is often not available. Here, we describe CETCh‐seq, a recently published method utilizing genome engineering with the CRISPR/Cas9 system to circumvent the (...) need for a specific antibody. Using the CETCh‐seq method, targeted genomic editing results in an epitope‐tagged transcription factor, which is recognized by a well‐characterized, standard antibody, efficacious for ChIP‐seq. We have used CETCh‐seq in human cancer cell lines as well as mouse embryonic stem cells. We find that roughly 60% of transcription factors tagged using CETCh‐seq produce a high quality ChIP‐seq map, a significant improvement over traditional antibody‐based methods. (shrink)

There is currently little empirical information about attitudes towards cognitive enhancement - the use of pharmaceutical drugs to enhance normal brain functioning. It is claimed this behaviour most commonly occurs in students to aid studying. We undertook a qualitative assessment of attitudes towards cognitive enhancement by conducting 19 semi-structured interviews with Australian university students. Most students considered cognitive enhancement to be unacceptable, in part because they believed it to be unethical but there was a lack of consensus on whether it (...) was similar or different to steroid use in sport. There was support for awareness campaigns and monitoring of cognitive enhancement use of pharmaceutical drugs. An understanding of student attitudes towards cognitive enhancement is important in formulating future policy. (shrink)

Thinking with Literature offers a succinct introduction to a cognitive literary criticsm, broad in scope but focusing on a particular cluster of approaches, some of which have so far been little used. Explanatory chapters and sections alternate with close readings of literary texts from a wide range of different periods and genres. The literary readings are not mere 'examples' of cognitive topics, still less of hypotheses in cognitive science: the central argument is that cognitive criticism must draw its primary energies (...) from the complexities of literature itself. The main objective of the book is to induce a change of perspective in the reader: to see the point, and the extreme interest, of adopting a cognitive approach to literary criticism. (shrink)

In recent years, political scientists have talked a great deal about the proper definition of their subject, and of how the ‘field’ of the political scientist is best distinguished from that of other social scientists. One proposal that is frequently made is that political science might quite properly be defined as the study of power, its forms, its sources, its distribution, its modes of exercise, its effects. The general justification for this proposal is, of course, that political activity itself appears (...) to be connected very intimately with power: it is often said that political activity is a struggle for power; that constitutions and other political institutions are methods of defining and regularising the distribution and the exercise of power, and so on. Since there seems to be some sense in which one can say that, within the wider area of social life, the political field is that which has some special connection with power, it may seem plausible then to suggest that the study of politics focusses upon the study of power. (shrink)

At the forefront of international concerns about global legislation and regulation, a host of noted environmentalists and business ethicists examine ethical issues in consumption from the points of view of environmental sustainability, economic development, and free enterprise.

Moral realism of a paradigmatic sort -- Defending the parallel -- The parity premise -- Epistemic nihilism -- Epistemic expressivism : traditional views -- Epistemic expressivism : nontraditional views -- Epistemic reductionism -- Three objections to the core argument.

Many philosophers hold antirealist views about morality, according to which moral facts or truths do not exist. Does this imply that other types of normative facts, such as epistemic facts, do not exist? The Normative Web develops a positive answer to this question. By means of an analogy between moral and epistemic facts, Terence Cuneo presents a compelling defence of robust realism in ethics. In so doing, he engages with a range of antirealist positions in epistemology such as error (...) theories, expressivist views, and reductionist views of epistemic reasons. (shrink)

I. Introduction : sortir du badiousisme Mehdi Belhaj Kacem a publié une longue lettre ouverte à Tristan Garcia où il décrit une “nouvelle conjecture” qui est en train d’émerger avec la génération montante des jeunes philosophes, qui commencent à se libérer de l’espace conceptuel défini par l’hégémonie intellectuelle exercée par Alain Badiou, pendant la dernière décennie, comme Maître Penseur incontesté. Selon MBK une nouvelle configuration conceptuelle est en train de se former, et sa “lettre...

Our project in this essay is to showcase nonnaturalistic moral realism’s resources for responding to metaphysical and epistemological objections by taking the view in some new directions. The central thesis we will argue for is that there is a battery of substantive moral propositions that are also nonnaturalistic conceptual truths. We call these propositions the moral fixed points. We will argue that they must find a place in any system of moral norms that applies to beings like us, in worlds (...) similar to our own. By committing themselves to true propositions of these sorts, nonnaturalists can fashion a view that is highly attractive in its own right, and resistant to the most prominent objections that have been pressed against it. (shrink)

This extended investigation of the semantics of event (and state) sentences in their various forms is a major contribution to the semantics of natural language, simultaneously encompassing important issues in linguistics, philosophy, and logic. It develops the view that the logical forms of simple English sentences typically contain quantification over events or states and shows how this view can account for a wide variety of semantic phenomena. Focusing on the structure of meaning in English sentences at a &"subatomic&" level&-that is, (...) a level below the one most theories accept as basic or &"atomic&"&-Parsons asserts that the semantics of simple English sentences require logical forms somewhat more complex than is normally assumed in natural language semantics. His articulation of underlying event theory explains a wide variety of apparently diverse semantic characteristics of natural language, and his development of the theory shows the importance of seeing the distinction between events and states. Parsons demonstrates that verbs, also, indicate kinds of actions rather than specific, individual actions. Verb phrases, too, he argues, depend on modifiers to make their function and meaning in a sentence specific. An appendix gives many of the details needed to formalize the theory discussed in the body of the text and provides a series of templates that permit the generation of atomic formulas of English. (shrink)

Central to the lives of the religiously committed are not simply religious convictions but also religious practices. The religiously committed, for example, regularly assemble to engage in religious rites, including corporate liturgical worship. Although the participation in liturgy is central to the religious lives of many, few philosophers have given it attention. In this collection of essays, Terence Cuneo turns his attention to liturgy, contending that the topic proves itself to be philosophically rich and rewarding. Taking the liturgical practices (...) of Eastern Christianity as its focal point, Ritualized Faith examines issues such as what the ethical importance of ritualized religious activities might be, what it is to immerse oneself in such activities, and what the significance of liturgical singing and iconography are. In doing so, Cuneo makes sense of these liturgical practices and indicates why they deserve a place in the religiously committed life. (shrink)

There is no greater testament to Emmanuel Levinas' reputation as an enigmatic thinker than in his meditations on eschatology and its relevance for contemporary thought. Levinas has come to be seen as a principal representative in Continental philosophy - alongside the likes of Heidegger, Benjamin, Adorno and Zizek - of a certain philosophical messianism, differing from its religious counterpart in being formulated apparently without appeal to any dogmatic content. To date, however, Levinas' messianism has not received the same detailed attention (...) as other aspects of his wide ranging ethical vision. Terence Holden attempts to redress this imbalance, tracing the evolution of the messianic idea across Levinas' career, emphasising the transformations or indeed displacements which this idea undergoes in taking on philosophical intelligibility. He suggests that, in order to crack the enigma which this idea represents, we must consider not only the Jewish tradition from which Levinas draws inspiration, but also Nietzsche, who ostensibly would represent the greatest rival to the messianic idea in the history of philosophy, with his notion of the ‘parody' of messianism. >. (shrink)

Human cooperation is held to be an evolutionary puzzle because people voluntarily engage in costly cooperation, and costly punishment of non-cooperators, even among anonymous strangers they will never meet again. The costs of such cooperation cannot be recovered through kin-selection, reciprocal altruism, indirect reciprocity, or costly signaling. A number of recent authors label this behavior ‘strong reciprocity’, and argue that it is: (a) a newly documented aspect of human nature, (b) adaptive, and (c) evolved by group selection. We argue exactly (...) the opposite; that the phenomenon is: (a) not new, (b) maladaptive, and (c) evolved by individual selection. In our perspective, the apparent puzzle disappears to reveal a biological and evolutionary logic to human cooperation. Group selection may play a role in theory, but it is neither necessary nor sufficient to explain human cooperation. Our alternative solution is simpler, makes fewer assumptions, and is more parsimonious with the empirical data. (shrink)

A new relationship between Aboriginal peoples and other Canadians is central for Canada's future, but the issues it presents may also be a portent of things to come for us all with increasing globalization. What is entailed in fashioning a viable and just Canadian society and state in which distinct Aboriginal peoples or nations can not only survive and break out of a colonial past, but flourish, especially in an increasingly global economy with its homogenizing pressures? This essay provides an (...) overview of the issues. Following a brief historical survey of the relationship between the Aboriginal peoples and the newcomers in Canada, the political and economic challenges in forming a more just relationship are outlined together with some of the competing visions, social policy options, and current mechanisms for effecting such. Next, some of the pressures on civil society and needed changes this generates are noted. Finally, the religious dimension in all of this, especially the peculiar situation of the churches, is briefly described, including the churches' tainted past, and yet their promising new role emerging as they come to terms with this past and seek to forge new relationships within their own communities. (shrink)

In a laboratory experiment, we use a public goods game to examine the hypothesis that human subjects use an involuntary eye-detector mechanism for evaluating the level of privacy. Half of our subjects are “watched” by images of a robot presented on their computer screen. The robot—named Kismet and invented at MIT—is constructed from objects that are obviously not human with the exception of its eyes. In our experiment, Kismet produces a significant difference in behavior that is not consistent with existing (...) economic models of preferences, either self- or other-regarding. Subjects who are “watched” by Kismet contribute 29% more to the public good than do subjects in the same setting without Kismet. (shrink)

In this book Terence Parsons revives the older tradition of taking such objects at face value. Using various modern techniques from logic and the philosophy of language, he formulates a metaphysical theory of nonexistent objects. The theory is given a formalization in symbolism rich enough to contain definite descriptions, modal operators, and epistemic contexts, and the book includes a discussion which relates the formalized theory explicitly to English.

Terence Cuneo presents a new argument for moral realism. According to the normative theory of speech, speech acts are generated by an agent's altering her normative position with regard to her audience. In doing so she takes on rights and responsibilities, some of which are moral and objective: these are a necessary condition of speech.

Exploring Aristotle's philosophical method and the merits of his conclusions, Irwin here shows how Aristotle defends dialectic against the objection that it cannot justify a metaphysical realist's claims. He focuses particularly on Aristotle's metaphysics, epistemology, philosophy of mind, and ethics, stressing the connections between doctrines that are often discussed separately.

We argue that the letter of the Extended Mind hypothesis can be accommodated by a strongly internalist, broadly Cartesian conception of mind. The argument turns centrally on an unusual but highly plausible view on the mark of the mental.

Since the 1950s, Terence Penelhum has been a leading contributor to studies on the thought of David Hume. In this collection, he presents a selection of the best of his essays on Hume. Most of the essays are quite recent and three are previously unpublished.

Terence Irwin presents a historical and critical study of the development of moral philosophy over two thousand years, from ancient Greece to the Reformation. Starting with the seminal ideas of Socrates, Plato, and Aristotle, he guides the reader through the centuries that follow, introducing each of the thinkers he discusses with generous quotations from their works. He offers not only careful interpretation but critical evaluation of what they have to offer philosophically. This is the first of three volumes which (...) will examine the history of ethics in the Socratic tradition, up to the late 20th century. (shrink)

This exceptional book examines and explains Plato's answer to the normative question, "How ought we to live?" It discusses Plato's conception of the virtues; his views about the connection between the virtues and happiness; and the account of reason, desire, and motivation that underlies his arguments about the virtues. Plato's answer to the epistemological question, "How can we know how we ought to live?" is also discussed. His views on knowledge, belief, and inquiry, and his theory of Forms, are examined, (...) insofar as they are relevant to his ethical view. Terence Irwin traces the development of Plato's moral philosophy, from the Socratic dialogues to its fullest exposition in the Republic. Plato's Ethics discusses Plato's reasons for abandoning or modifying some aspects of Socratic ethics, and for believing that he preserves Socrates' essential insights. A brief and selective discussion of the Statesmen, Philebus, and Laws is included. Replacing Irwin's earlier Plato's Moral Theory (Oxford, 1977), this book gives a clearer and fuller account of the main questions and discusses some recent controversies in the interpretation of Plato's ethics. It does not presuppose any knowledge of Greek or any extensive knowledge of Plato. (shrink)

This chapter suggests that evidence should be viewed as a field of study, one to which most disciplines could contribute and from which most could benefit, and that generalisations should be viewed as part of that field. Every argument must be based upon a generalisation that can be stated as a major premise. The relationship between a supporting proposition or propositions and an inferred proposition can be restated in a quasi-deductive form by identifying the generalisation upon which the inference depends. (...) A datum or a proposition can be evidence if and only if it alters the probability, positively or negatively, of a proposition to be inferred. In order to demonstrate that an evidential proposition is relevant, an analyst must be able to identify and articulate a generalisation that justifies the claim that the evidential proposition alters the probability of an inferred proposition. This chapter develops these ideas and presents a method of generalisation-analysis. It also argues that generalisation-analysis is a tool in the field of evidence that could be useful in analysing and critiquing arguments in many disciplines. (shrink)